NR AXZW
AU Adjou,K.T.; Allix,S.; Ouidja,M.O.; Backer,S.; Couquet,C.; Cornuejols,M.J.; Deslys,J.P.; Brugere,H.; Brugere-Picoux,J.; El-Hachimi,K.H.
TI Alpha-synuclein accumulates in the brain of scrapie-affected sheep and goats
QU Journal of Comparative Pathology 2007 Jul; 137(1): 78-81
PT journal article; research support, non-u.s. gov't
AB Immunohistochemical examination demonstrated widespread granular deposits of alpha-synuclein (alphaSN) in the brains of sheep and goats with natural scrapie, especially in the cornu ammonis and subiculum of the hippocampus; this contrasted with the diffuse and non-granular immunolabelling seen in healthy controls. There was non-regular "co-localization" of PrPsc and alphaSN. The findings resembled those reported in Creutzfeldt-Jakob disease and in experimental prion disease in hamsters and mice. The results suggest that perturbation of alphaSN metabolism plays a role in human and animal prion diseases.
MH Animals; Brain/*metabolism/pathology; Female; Gene Expression Regulation; Goat Diseases/*metabolism/pathology; Goats; Prions/genetics/metabolism; Scrapie/*metabolism/pathology; Sheep; alpha-Synuclein/genetics/*metabolism
AD Ecole Nationale Veterinaire d'Alfort (Laboratoire de Pathologie Medicale du Betail and Service de Physiologie et Therapeutique), 7 Avenue du General de Gaulle, 94 704 Maisons-Alfort, Cedex. kadjou@vet-alfort.fr
SP englisch
PO England