NR AXYS
AU White,S.; O'Rourke,K.; Mousel,M.; Spraker,T.
TI Combining Information on Cation Levels Improves Association with Chronic Wasting Disease in Elk
QU International Conference - Prion 2007 (26.-28.9.2007) Edinburgh International Conference Centre, Edinburgh, Scotland, UK - Book of Abstracts: Epidemiology, Risk Assessment and Transmission P04.10
IA http://www.prion2007.com/pdf/Prion Book of Abstracts.pdf
PT Konferenz-Poster
AB
Background: Levels of divalent cations have been suggested as a tool for addressing transmissible spongiform encephalopathies (TSEs).
Aims/Objectives: This study examined potential relationships between chronic wasting disease (CWD) and brain levels of six divalent cations in 173 elk.
Methods: Cation levels were measured in ug/g, and relationships with CWD were assessed using logistic regression.
Results: Magnesium has been little studied in TSEs, but the CWD positive elk in this study had significantly lower brain magnesium than CWD negative elk. The use of manganese levels in addition to magnesium levels in a bivariate model significantly refined explanatory ability, even though manganese was not significantly associated with CWD by itself.
Discussion: Elevated levels of manganese have been reported in several TSEs, and a similar trend was responsible for the improved explanatory ability of the model for CWD in elk. This study demonstrates the usefulness of combining information from multiple sources, and suggests that magnesium levels may provide an important additional source of information for TSE research.
AD S. White, K. O'Rourke, USDA-ARS Animal Disease Unit, USA; M. Mousel, USDA-ARS US Sheep Experiment Station, USA; T. Spraker, Colorado State University, USA
SP englisch
PO Schottland
EA pdf-Datei und Poster (Posterautoren ergänzt um T. Gidlewski und K. VerCauteren)