NR AXRE
AU Lescoutra-Etchegaray,N.; Ruchoux,M.M.; Correia,E.; Jolit,A.; Freire,S.; Lasmezas,C.I.; Deslys,J.P.; Comoy,E.
TI Case Report of Variant Creutzfeldt-Jakob Disease in a Macaque after Blood Transfusion
QU International Conference - Prion 2007 (26.-28.9.2007) Edinburgh International Conference Centre, Edinburgh, Scotland, UK - Book of Abstracts: Epidemiology, Risk Assessment and Transmission P04.49
IA http://www.prion2007.com/pdf/Prion Book of Abstracts.pdf
PT Konferenz-Poster
AB
A fourth human case of probable transmission of vCJD through transfusion has now been reported but a number of features affecting transfusion-related infection remain imprecise, including infectious dose, length of incubation period and critical infectious window of blood donors.
We report here the first case of experimental transmission of vCJD in primates by blood transfusion. Experimental infection of Cynomolgus macaque has been demonstrated to be a sensitive model for the investigation of human prion diseases, inducing similar distribution of infectivity in peripheral lymphoid tissues and equivalent brain pathology. In our study, transfusion was performed with 40 ml of whole blood drawn from a vCJD-infected macaque at the terminal stage of the disease. Clinical symptoms of vCJD appeared in the recipient animal after five years of incubation. The total amount of infectivity in the transfused blood was approximately 106 fold lower than in the brain (titration still in progress). In several animals infected intravenously with brain homogenate, the presence of PrPres in serial lymph nodes biopsies and in other organs at autopsy was examined and results will be presented.
AD N. Lescoutra-Etchegaray, M.M. Ruchoux, E. Correia, A. Jolit, S. Freire, J.P. Deslys, E. Comoy, CEA/DSV/IMETI/SEPIA, France; C.I. Lasmezas, Scripps Florida, USA
SP englisch
PO Schottland
EA pdf-Datei und Poster (Postertitel: vCJD in a macaque after blood transfusion)