NR AXPU
AU Kelly,C. et al.
TI Prevalence of Abnormal Prion Protein in the Population of Great Britain (GB) - Initial Results from Large-scale Tonsil Testing
QU International Conference - Prion 2007 (26.-28.9.2007) Edinburgh International Conference Centre, Edinburgh, Scotland, UK - Book of Abstracts: Oral Abstracts FC5.2
IA http://www.prion2007.com/pdf/Prion Book of Abstracts.pdf
PT Konferenz-Vortrag
AB The Spongiform Encephalopathy Advisory Committee (SEAC) recommended that more measures of PrPTSE (a marker for variant Creutzfeldt-Jakob Disease (vCJD) infectivity) prevalence in the population of Great Britain (GB) are urgently required to inform decisions on surgical and dental instrument management and blood safety. The National Anonymous Tonsil Archive (NATA) was created for this purpose and aims to collect and test 100,000 tonsil pairs, approximately 25% of which will be in the 1961 to 1985 birth cohort, the cohort in which 83% of the vCJD cases to date has occurred. The current estimate of the prevalence of PrPTSE in the population of GB based on a retrospective study of archived appendix and tonsil tissue (Hilton et al, 2004). This study found three positive specimens out of 12,674, giving a prevalence of 237 per million (95% CI 49-692), and four-fifths of the study population was from the 10 to 30 year age group, roughly equivalent to the 1961 to 1985 birth cohort in the tonsil archive. Initial NATA results from testing around 20,000 specimens from those born before 1996 will be presented and prevalence estimates calculated.
AD C. Kelly, Health Protection Agency Centre for Infections, CJD Section, UK; Colleagues, Health Protection Agency, UK
SP englisch
PO Schottland