NR AXNV
AU Haik,S.; Galanaud,D.; Linguraru,M.G.; Peoc'h,K.; Privat,N.; Faucheux,B.A.; Ayache,N.; Hauw,J.J.; Dormont,D.; Brandel,J.P.
TI In Vivo Detection of Thalamic Gliosis: A Patho-Radiologic Demonstration in Familial Fatal Insomnia
QU International Conference - Prion 2007 (26.-28.9.2007) Edinburgh International Conference Centre, Edinburgh, Scotland, UK - Book of Abstracts: Pathology and Pathogenesis P03.60
IA http://www.prion2007.com/pdf/Prion Book of Abstracts.pdf
PT Konferenz-Poster
AB Increasing evidence supports the usefulness of brain MRI for the diagnosis of human prion diseases. From the neuroradiological point of view, fatal familial insomnia is probably the most challenging to diagnose because brain lesions are mostly confined to the thalamus. We report a patient with fatal familial insomnia and normal MRI images (including FLAIR sequence and diffusion-weighted imaging). Results of MR spectroscopy combined with the measurement of apparent diffusion coefficient of water in different brain areas were analyzed. Because the MRI study was performed only four days before patient death, we were able to compare radiological data with the lesions observed at the neuropathological level. The neuroradiological study showed, in the thalamus but not in the other brain regions studied, an increase of apparent diffusion coefficient of water and a metabolic pattern indicating of gliosis. These alterations closely correlated with neuropathological data showing an almost pure gliosis that was restricted to the thalami. Considering FFI as a model of thalamicrestricted gliosis, this case demonstrates that multisequences MR can detect prioninduced gliosis in vivo, as confirmed by a neuropathological examination performed only a few days after.
AD S. Haik, N. Privat, B. Faucheux, Salpetriere Hospital, IFR70, France; D. Galanaud, D. Dormont, AP-HP, Salpetriere Hospital, France; M. Linguraru, N. Ayache, INRIA, France; K. Peoc'h, Lariboisiere Hospital, France; J.J. Hauw, Salpetriere Hospital, France; J.P. Brandel, Salpetrière Hospital, France
SP englisch
PO Schottland
EA pdf-Datei und Poster (Posterautoren: S. Haik, D. Galanaud, B.A. Faucheux, N. Privat, M.G. Linguraru, N. Ayache, J.J. Hauw, D. Dormont und J.P. Brandel)