NR AXHZ
AU An,S.S.A.; Lim,K.T.; Oh,H.J.; Lee,B.S.; Fabre,G.; Segarra,C.; Ju,Y.R.; Yokoyama,T.; Kim,S.Y.; Andreoletti,O.; Coste,J.
TI Detection of PrPsc in Plasma from Scrapie Sheep in the Preclinical Stages Using a Multimer Detection System-3D
QU International Conference - Prion 2007 (26.-28.9.2007) Edinburgh International Conference Centre, Edinburgh, Scotland, UK - Book of Abstracts: Pathology and Pathogenesis P03.34
IA http://www.prion2007.com/pdf/Prion Book of Abstracts.pdf
PT Konferenz-Poster
AB MDS-3D was used to test 10 plasma samples from scrapie infected preclinical sheep in comparison with the normal controls. These sheep showed no symptoms and were naturally infected The sheep had the most susceptible genotype of VRQ/VRQ. We used MDS-3D as previously reported, which is based on the multimeric expression of epitopes on aggregated disease-associated prion protein, in contrast to the cellular form that is monomer. These characteristics enable the MDS-3D to distinguish infectious samples of scrapie sheep in preclinical stage vs normal sheep . The sensitivity and rapidness of the MDS-3D system demonstrated that this assay could be used in an automated screening system for monitoring the human samples to ensure the safety of blood and blood products.
AD S. An, K. Lim, H. Oh, B. Lee, PeopleBio Inc., Korea; G. Fabre, C. Segarra, J. Coste, EFS Pyrenees-Mediterranee, France; Y. Ju, Korean Center for Disease Control and Prevention, Korea; T. Yokoyama, National Institute of Animal Health, Prion Disease Research Center, Japan; S.Y. Kim, Seoul National University School of Medicine, Korea; O. Andreoletti, Ecole Nationale Veterinaire, France
SP englisch
PO Schottland
EA pdf-Datei und Poster (Autorenliste ergänzt um M.J. Schmerr)