NR AWVW
AU Anderson,C.A.; Bosque,P.; Filley,C.M.; Arciniegas,D.B.; Kleinschmidt-DeMasters,B.K.; Pape,W.J.; Tyler,K.L.
TI Colorado surveillance program for chronic wasting disease transmission to humans: lessons from 2 highly suspicious but negative cases.
QU Archives of Neurology 2007 Mar; 64(3): 439-41
PT case reports; journal article
AB OBJECTIVE: To describe 2 patients with rapidly progressive dementia and risk factors for exposure to chronic wasting disease (CWD) in whom extensive testing negated the possible transmission of CWD. Design/ METHODS: We describe the evaluation of 2 young adults with initial exposure histories and clinical presentations that suggested the possibility of CWD transmission to humans. Patients A 52-year-old woman with possible laboratory exposure to CWD and a 25-year-old man who had consumed meat from a CWD endemic area. INTERVENTIONS: Clinical evaluation, neuropathological examination, and genetic testing. RESULTS: Neuropathological and genetic assessment in the 2 patients proved the diagnoses of early-onset Alzheimer disease and a rare genetic prion disease. CONCLUSION: No convincing cases of CWD transmission to humans have been detected in our surveillance program.
MH Adult; Animals; Colorado/epidemiology; Disease Reservoirs; Female; *Health Surveys; Humans; Male; Middle Aged; Wasting Disease,; Chronic/diagnosis/*epidemiology/physiopathology/*transmission
AD Department of Neurology, University of Colorado Health Sciences Center, Denver, CO 80262, USA. al.anderson@uchsc.edu
SP englisch
PO USA