NR AWQE
AU Ward,H.J.T.; Everington,D.; Cousens,S.N.; Smith-Bathgate,B.; Gillies,M.; Murray,K.; Knight,R.S.G.; Smith,P.G.; Will,R.G.
TI Secondary transmission of sporadic Creutzfeldt-Jakob disease via surgery in the UK?
QU International Conference - Prion 2006: Strategies, advances and trends towards protection of society - 3.10.-6.10.2006, Torino, Italy, Lingotto Conference Centre - Poster sessions EPI-26
PT Konferenz-Poster
AB Sporadic Creutzfeldt-Jakob disease (sCJD) is the most common form of the human TSEs. The disease-associated form of the prion protein, PrPsc, is the principle component of the sCJD infectious agent, but how or even whether it is acquired remains uncertain. Until recently, the sCJD agent was thought to be primarily confined to the central and peripheral nervous systems. However, the use of increasingly sensitive techniques has enabled abnormal prion protein to be detected in some peripheral tissues of sCJD cases, including skeletal muscle and spleen. These data, together with strong evidence of transmission of variant CJD through blood, and the relative resistance of PrPsc to routine decontamination processes, have led to increased concern that sCJD might be transmitted through routine surgery. This study describes the first analysis of reported surgical histories from a large series of sCJD cases (n=370) and general population controls (n=922) from Great Britain. The results of this analysis will be compared with those from two large case-control studies carried out previously in Australia and Europe. Temporal and geographical links will be described between sCJD cases (n=697), who underwent neurological and gynaecological surgical procedures in the UK, to determine whether it is plausible that transmission could have occurred through contaminated instruments during these procedures.
AD H.J.T. Ward, D. Everington, B. Smith-Bathgate, M. Gillies, K. Murray, R.S.G. Knight, R.G. Will: National Creutzfeldt-Jakob Disease Surveillance Unit, Edinburgh, UK; S.N. Cousens, P.G. Smith: 2London School of Hygiene & Tropical Medicine, London, UK. E-mail: h.ward@ed.ac.uk
SP englisch
PO Italien