NR AWOH
AU Spraker,T.R.
TI Pathological lesions associated with Chronic Wasting Disease
QU International Conference - Prion 2006: Strategies, advances and trends towards protection of society - 3.10.-6.10.2006, Torino, Italy, Lingotto Conference Centre, Workshop of the Neuroprion Cervid Group - Chronic Wasting Disease (CWD): Current knowledge and European perspective 2006, 3.10.2006
PT Konferenz-Vortrag
AB The pathological lesions of chronic wasting disease (CWD) are similar to other TSE's. Gross lesions are primarily observed in terminal stage of CWD. Gross lesions include emaciation, generalized serous atrophy of adipose tissues, and mild atrophy of lymphoid tissues. Bronchopneumonia is commonly found, especially in elk. In captive deer it is common to find the rumen partially filled with water. Abomasal ulcers are occasionally seen in mule deer, but have not been seen in elk. Immunohistochemistry staining is first observed in lymphoid tissues of the head. Internal and peripheral lymphoid tissues accumulate PRPcwd early in the disease course, but appear to follow the cranial lymphoid tissues. Nerves of the intestinal mucosa and myenteric plexuses begin to accumulate PRPcwd early. A minimal amount of PRPcwd can be seen in the vagus nerve adjacent to the trachea and in the spinal cord. PRPcwd first accumulates in the vagus nucleus of the brain stem the spreads through out the rest of the brain. The cerebellum accumulates PRPcwd last. The earliest histological lesions can be found in the vagus nucleus and are characterized by mild astrocytic hypertrophy and proliferation followed by spongiform degeneration of the neuropil. Vacuolization of the neuronal perikarya, neuronal denrites and axons follow. Neuronal degeneration and dropout appears to be the last change to occur. Spongiform degeneration follows the distribution of PRPcwd. To date, areas of spongiform degeneration free of PRPcwd demonstrated by IHC have not been found. There is no evidence of edema, suppurative or non-suppurative encephalitis in these areas of spongiform degeneration.
AD Spraker College of Veterinary Medicine and Biomedical Sciences, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, 80526 USA
SP englisch
PO Italien