NR AWNR
AU Silva,J.F.; Correia,J.J.; Ribeiro,J.; Carmo,S.; Orge,L.
TI Feline spongiform encephalopathy: first confirmed case reported in Portugal
QU International Conference - Prion 2006: Strategies, advances and trends towards protection of society - 3.10.-6.10.2006, Torino, Italy, Lingotto Conference Centre - Poster sessions DIA-45
PT Konferenz-Poster
AB Feline spongiform encephalopathy (FSE), affecting domestic and captive feline species, is a prion disease considered to be related to bovine spongiform encephalopathy (BSE). Here we report the first case diagnosed in Portugal, highlighting the neuroapthological findings. In 2004 a 9-year old intact female Siamese cat was referred with chronic progressive behavioural changes, polydipsia, gait abnormalities and episodes of hypersalivation. Clinical signs progressed to tetraparesis and dementia and euthanasia was performed. At necropsy, brain and spinal cord had no significative changes. Tissue samples from brain, cerebellum, brainstem and spinal cord were collected for histopathology and immunohistochemistry for detection of PrPres. Histology revealed neuropil and neuronal perikarion vacuolation in several areas of the central nervous system together with gliosis and cell rarefaction at the granular layer of the cerebellum. Immunohistochemical detection of PrPres showed a strong and widespread PrPres accumulation as granular and linear deposits as well as associated with some neurons. These findings are supportive of FSE. To the authors knowledge this is the first confirmed case of FSE reported in Portugal.
AD J.F. Silva, J.J. Correia: Faculdade de Medicina Veterinária (UTL), Lisbon, Portugal; J. Ribeiro, S. Carmo: Clínica Veterinária Ani+, Queluz, Portugal; L. Orge: Laboratório Nacional de Investigação Veterinária, Unidade de BSE, Lisbon, Portugal
SP englisch
PO Italien