NR AWLV
AU Perucchini,M.; Charlesworth,B.; Pemberton,J.; Miller,M.W.; Baeten,L.A.; Hunter,N.; Goldmann,W.
TI Genetic variability and selection of the cervus elaphus prion (Prp) gene
QU International Conference - Prion 2006: Strategies, advances and trends towards protection of society - 3.10.-6.10.2006, Torino, Italy, Lingotto Conference Centre - Poster sessions GEN-24
PT Konferenz-Poster
AB Variation in the sequence of the PrP prion gene has been shown to modulate the susceptibility of Chronic Wasting Disease (CWD), a neurodegenerative disorder affecting cervid populations in North America. Despite their close phylogenetic relationship, European cervid populations are currently considered CWD free. We will present data on the selective forces acting on the PrP gene of Cervus elaphus, based on the analysis of the patterns of nucleotide variation in the PrP gene of two target C. elaphus populations: European red deer from the Scottish Isle of Rhum and North American elk from Colorado. The investigation of CWD-affected and CWD-free elk aimed at determining the presence or absence of disease specific selection and the role of PrP variants which appear to be associated with disease modulation. A number of novel nonsynonymous cervid polymorphisms were identified: codon 168 in deer, and codon 25 and 191 in elk. Polymorphism M132L which had been previously associated with CWD-susceptibility in elk was found in the Colorado elk population, but not in the red deer. The relationship between genotypic frequencies and disease will be discussed. Other codons which have been associated with CWD modulation in other cervid species were not found to be polymorphic in the two studied populations.
AD M. Perucchini, N. Hunter, W. Goldmann: Institute for Animal Health, Neuropathogenesis Unit, Edinburgh, UK; B. Charlesworth, J. Pemberton: Institute of Evolutionary Biology, University of Edinburgh, West Mains Rd, Edinburgh, UK; M. Miller, L. Baeten: Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, Colorado, USA. E-mail: matteo.perucchini@bbsrc.ac.uk
SP englisch
PO Italien