NR AWKF
AU Miller,M.W.
TI Epidemiology of chronic wasting disease in North American cervids
QU International Conference - Prion 2006: Strategies, advances and trends towards protection of society - 3.10.-6.10.2006, Torino, Italy, Lingotto Conference Centre - Oral sessions ORAL-04
PT Konferenz-Vortrag
AB Chronic wasting disease (CWD) occurs naturally in North American deer (Odocoileus spp.), wapiti, and moose (collectively called "cervids"). CWD presently occurs in scattered foci throughout North America, both in the wild and in commercial facilities. CWD is contagious among its natural hosts, and epidemics can persist under both captive and free-ranging conditions, resulting in remarkably high infection rates. The precise mechanism of contagion remains unclear, although accumulations of disease-associated prion protein (PRPcwd) in lymphatic tissues associated with the gastrointestinal tract suggest shedding via feces and perhaps saliva. Analyses of epidemic data suggest that indirect (animal-environment-animal) transmission may be the dominant force in epidemic dynamics, and the CWD agent has been shown to persist in environments contaminated by excreta or carcass remains for years. Variation in cellular prion protein appears to influence CWD pathogenesis, and may provide a biological mechanism for emergence of variant strains within and among the four naturally susceptible species. The long-term implications of CWD for public, livestock, and wildlife health remain uncertain. Unfortunately, limitations of existing technology available to combat prion diseases make control of CWD ineffective or infeasible under most conditions.
AD Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, Colorado, USA
SP englisch
PO Italien