NR AWIH
AU Kranich,J.; Schwarz,P.; Miele,G.; Julius,C.; Heppner,F.; Pedersen,J.; Aguzzi,A.
TI The role of MFG-E8 in prion pathogenesis
QU International Conference - Prion 2006: Strategies, advances and trends towards protection of society - 3.10.-6.10.2006, Torino, Italy, Lingotto Conference Centre - Oral sessions ORAL-38
PT Konferenz-Vortrag
AB Aberrations in the removal of apoptotic cells in the brain may influence clearance of prions and degradation of PrPsc. We have addressed this question with mice deficient for milk fat globule epidermal growth factor 8 (MFG-E8), a secreted glycoprotein mainly expressed by peritoneal macrophages, immature dendritic cells, tingible body macrophages and follicular dendritic cells. MFG-E8 acts as a bridge linking apoptotic and phagocytic cells, and therefore directly mediates the uptake of the apoptotic cell by the phagocyte. MFG-E8 is also expressed in the brain, suggesting also a role in removal of apoptotic cells in the CNS. MFG-E8-/- mice show profound acceleration in prion pathogenesis after intracerebral inoculation and a less pronounced acceleration after intraperitoneal inoculation. MFG-E8-/- mice have increased levels of PrPsc in the brain at terminal stage. These results suggest an involvement of MFG-E8 in prion clearance.
AD University Hospital Zürich, Institute of Neuropathology, Zürich, Switzerland. E-mail: Jan.Kranich@usz.ch
SP englisch
PO Italien