NR AVYW
AU Silveyra,M.X.; Garcia-Ayllon,M.S.; Calero,M.; Saez-Valero,J.
TI Altered glycosylation of acetylcholinesterase in the Creutzfeldt-Jakob cerebrospinal fluid
QU Journal of Molecular Neuroscience 2006 Sep; 30(1-2): 65-6
PT comparative study; journal article; research support, non-u.s. gov't
AB Several neurodegenerative disorders present deficiencies in the cholinergic system. Scarce research on prion encephalopathies has examined the levels of cholinergic pathway-related enzymes. Acetylcholinesterase (AChE) is expressed as several molecular forms. The potential importance of these variants is increased by the possibility that AChE has roles other than acetylcholine hydrolysis. We investigated the levels of AChE, its molecular forms, and glycosylation in the cerebrospinal fluid (CSF) from Creutzfeldt-Jakob disease (CJD) patients.
MH Acetylcholinesterase/*cerebrospinal fluid; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid/enzymology; Glycosylation; Humans; Reference Values
AD Maria-Ximena Silveyra, Maria-Salud García-Ayllón, Javier Sáez-Valero, Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC, San Juan de Alicante, Spain; Miguel Calero, Unidad de Encefalopatías Espongiformes, Centro Nacional de Microbiología, Instituto de Salud Carlos III, Majadahonda, Madrid, Spain
SP englisch
PO USA