NR AVUF
AU Klein,M.A.
TI Prion diseases and neuroinvasion
QU Schweizer Archiv für Neurologie und Psychiatrie. Archives Suisses de Neurologie et de Psychiatrie. Archivio Svizzero di Neurologia e Psichiatria 2001; 152(2): 50-4
IA http://www.sanp.ch/pdf/2001/2001-02/2001-02-010.PDF
PT Review
AB Prion diseases are lethal neurodegenerative disorders affecting animals and humans. Although human prion diseases are generally rare, the incidence of a "new variant" Creutzfeldt-Jakob disease in young patients in the United Kingdom is increasing. Considerable evidence suggests that this novel disease is the sequelae of exposure to BSE-contaminated food products. Recently several clues have been identified regarding the mechanisms of prion spread in an infected host following peripheral infection. In this article the involvement of the immune system in the mechanism of prion spread from peripheral sites to the central nervous system will be discussed. These studies will help to establish strategies aimed at therapy for iatrogenic prion disease and new variant Creutzfeldt-Jakob disease (vCJD) in humans.
ZR 22
AD Michael A. Klein (mak_ub@yahoo.com), Institute of Pathology, Kantonsspital, CH-4003 Basel
SP Multiple languages
PO Schweiz