NR AVQS
AU Fukuuchi,T.; Doh-ura,K.; Yoshihara,S.; Ohta,S.
TI Metal complexes with superoxide dismutase-like activity as candidates for anti-prion drug
QU Bioorganic & Medicinal Chemistry Letters 2006 Dec 1; 16(23): 5982-7
PT journal article
AB Various compounds were evaluated for ability to inhibit the formation of the abnormal protease-resistant form of prion protein (PrP-res) in two cell lines infected with different prion strains. Examination of the structure-activity relationships indicated that compounds with copper-selective chelating ability and whose copper complexes have high SOD-like activity are candidates for anti-prion drug.
MH Cell Line; Chelating Agents/*chemistry/*pharmacology; Copper/*chemistry/*metabolism; Molecular Structure; Prions/*metabolism; Spectrum Analysis; Structure-Activity Relationship; Superoxide Dismutase/*antagonists & inhibitors/*metabolism
AD
Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8553, Japan. t-fukuu@ps.hirokoku-u.ac.jp
SP englisch
PO England