NR AVNO
AU Kocisko,D.A.; Caughey,B.W.; Morrey,J.D.; Race,R.E.
TI Enhanced antiscrapie effect using combination drug treatment
QU Antimicrobial Agents and Chemotherapy 2006 Oct; 50(10): 3447-9
PT journal article; research support, n.i.h., extramural; research support, n.i.h., intramural; research support, u.s. gov't, non-p.h.s.
AB Combination treatment with pentosan polysulfate and Fe(III)meso-tetra(4-sulfonatophenyl)porphine in mice beginning 14 or 28 days after scrapie inoculation significantly increased survival times. This increase may be synergistic, implying that the compounds act cooperatively in vivo. Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases.
MH Animals; Cricetinae; Drug Synergism; Drug Therapy, Combination; Mice; *Pentosan Sulfuric Polyester/administration & dosage/therapeutic use; *Porphyrins/administration & dosage/therapeutic use; Scrapie/*drug therapy/mortality; Survival Rate; Treatment Outcome
AD Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA. DKocisko@niaid.nih.gov
SP englisch
PO USA