NR AVFL
AU Eiden,M.; Buschmann,A.; Kupfer,L.; Groschup,M.H.
TI Synthetic prions
QU Journal of Veterinary Medicine. Series B, Infectious Diseases and Veterinary Public Health 2006 Aug; 53(6): 251-6
PT journal article; review
AB The prion theory postulates that prions are novel infectious agents that are composed largely, if not entirely, of abnormally folded host-encoded prion proteins. However, the existence of different prion strains is enigma, if these novel infectious agents lack a genetic element, such as a nucleic acid. The best proof for this 'protein-only' concept would be the in vitro generation of prions from synthetic sources. Indeed, a substantial body of evidence has meanwhile been accumulated in favour of this postulate. This mini review recapitulates all relevant studies and experimental data on the generation of synthetic prions.
ZR 53
MH Animals; Central Nervous System Diseases/pathology/*veterinary/virology; Humans; Prion Diseases/pathology/*veterinary/virology; Prions/*analysis/chemistry
AD Institute for Novel and Emerging Infectious Diseases (INEID) at the Friedrich-Loeffler-Institut, Boddenblick 5a, 17493 Greifswald-Insel Riems, Germany.
SP englisch
PO Deutschland