NR AVAU
AU Holsinger,R.M.; Lee,J.S.; Boyd,A.; Masters,C.L.; Collins,S.J.
TI CSF BACE1 activity is increased in CJD and Alzheimer disease other dementias
QU Neurology 2006 Aug 22; 67(4): 710-2
PT controlled clinical trial; journal article
AB To assess the diagnostic utility of CSF BACE1 activity for discriminating Alzheimer disease (AD) from other dementias, particularly Creutzfeldt-Jakob disease (CJD), the authors studied 26 patients with sporadic CJD, 21 patients with AD, and 21 patients with various non-AD, non-CJD dementias (DCs). CSF BACE1 activity was elevated in AD in comparison with DC (p = 0.01). Unexpectedly, CSF BACE1 activity was also increased in sporadic CJD (p = 0.02).
MH 14-3-3 Proteins/*cerebrospinal fluid; Aged; Alzheimer Disease/*cerebrospinal fluid/*diagnosis/epidemiology; Australia/epidemiology; Biological Markers/cerebrospinal fluid; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid/*diagnosis/epidemiology; Dementia/cerebrospinal fluid/diagnosis/epidemiology; Diagnosis, Differential; Endopeptidases/*cerebrospinal fluid; Enzyme Activation; Female; Humans; Male; Nerve Tissue Proteins/*cerebrospinal fluid; Reproducibility of Results; Risk Assessment/methods; Risk Factors; Sensitivity and Specificity
AD University of Melbourne, Parkville, Victoria, 3010, Australia. d.holsinger@fhs.usyd.edu.au
SP englisch
PO USA