NR AUTO
AU Cervenakova,L.; Yakovleva,O.; McKenzie,C.
TI Protease-resistant prion protein in lymphoreticular tumors of variant Creutzfeldt-Jakob disease mice
QU Emerging Infectious Diseases 2006 Mar; 12(3): 511-3
PT journal article
AB We report protease-resistant prion protein (PrPres) in spontaneous lymphoreticular tumors of mice infected with the agent of variant Creutzfeldt-Jakob disease (vCJD). PrPres may accumulate in lymphoreticular system tumors of asymptomatic persons with vCJD. The statistical power of estimates of vCJD prevalence might be increased by expanding screening to include samples of lymphoreticular neoplasms.
MH Animals; Creutzfeldt-Jakob Syndrome/*complications/*pathology; Female; Humans; Lymphoid Tissue/metabolism/*pathology; Mice; Neoplasms/*complications/*metabolism/pathology; Peptide Hydrolases/*metabolism; Prions/*metabolism
AD Transmissible Diseases Department, J.H. Holland Laboratory, American Red Cross, Rockville, Maryland 20855, USA. cervenakl@usa.redcross.org
SP englisch
PO USA