NR AUOS
AU Stoeck,K.; Bodemer,M.; Zerr,I.
TI Pro- and anti-inflammatory cytokines in the CSF of patients with Creutzfeldt-Jakob disease
QU Journal of Neuroimmunology 2006 Mar; 172(1-2): 175-81
PT journal article
AB We investigated cerebrospinal fluid (CSF) samples from patients with Creutzfeldt-Jakob disease (CJD) and other neurological diseases. Concentrations of pro- and anti-inflammatory cytokines IL-1ß, IL-6, IL-8, IL-12, TNF-alpha and TGF-beta 2 were determined in CSF using ELISA. Significant changes were found for IL-8 and TGF-beta 2. IL-8 levels were elevated in the CSF of CJD patients. Of interest, the increase was significant to other dementia and to controls. In contrast, TGF-beta 2 was significantly decreased in CSF of CJD compared to all groups. IL-1ß, IL-12 and TNF-alpha could not be detected in CSF or in case of IL-6 in only low concentrations without significant difference.
MH Adolescent; Adult; Aged; Central Nervous System Diseases/cerebrospinal fluid/complications; Comparative Study; Creutzfeldt-Jakob Syndrome/blood/*cerebrospinal fluid/diagnosis; Dementia/cerebrospinal fluid/complications; Enzyme-Linked Immunosorbent Assay/methods; Epilepsy/cerebrospinal fluid/complications; Female; Humans; Inflammation/*cerebrospinal fluid/etiology; Interleukin-8/blood/*cerebrospinal fluid; Male; Middle Aged; Research Support, Non-U.S. Gov't; Sensitivity and Specificity; Statistics, Nonparametric; Transforming Growth Factor beta/blood/*cerebrospinal fluid
AD Department of Neurology, University of Göttingen, Robert-Koch Str.40, 37075 Göttingen, Germany.
SP englisch
PO Niederlande