NR AULF
AU Lantier,F.; Berthon,P.; Sarradin,P.; Khang,J.V.T.; Elsen,J.M.
TI Genetics of animal spongiform encephalopathies
QU Medecine et Maladies Infectieuses 1996; 26(BIS): 259-63
PT Article
AB Genetic control of sheep resistance to Scrapie (Tremblante) is well established. The incubation period of the natural or experimental disease is strongly associated with polymorphisms of codons 136 (Ala/Val) and 171 (Arg/Glu) from the Prion protein PrP. However, all of the observed genetic variability can't be related to these polymorphisms and other mutations of the PrP gene, or/and other genes, are probably concerned with the host susceptibility to spongiform encephalopathies. The resistance of immunodeficient mice (SCID mice) to the dissemination of pathogens in their bodies suggests a role of immune cells. A local inflammatory reaction (astrocytosis, microgliosis, secretion of interleukin-1 and TNF-alpha) has been demonstrated in the central nervous system. A possible role in the regulation of the incubation period or expression of the disease by genes of the immune system (genes of the major histocompatibility complex, of cytokines and membrane receptors, etc) remains to be studied, in particular during the early phases of infection during which we have at present no means of detecting affected animals.
ZR 30
SP französisch