NR AUBE
AU Kocisko,D.A.; Caughey,W.S.; Race,R.E.; Roper,G.; Caughey,B.W.; Morrey,J.D.
TI A porphyrin increases survival time of mice after intracerebral prion infection
QU Antimicrobial Agents and Chemotherapy 2006 Feb; 50(2): 759-61
PT journal article
AB Prion diseases, including scrapie, are incurable neurodegenerative disorders. Some compounds can delay disease after a peripheral scrapie inoculation, but few are effective against advanced disease. Here, we tested multiple related porphyrins, but only Fe(III)meso-tetra(4-sulfonatophenyl)porphine injected into mouse brains after intracerebral scrapie inoculation substantially increased survival times.
MH Animals; Blood-Brain Barrier; Mice; Mice, Transgenic; Porphyrins/pharmacokinetics/*therapeutic use; Prion Diseases/*drug therapy; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, Non-P.H.S.
AD Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 903 S. 4th Street, Hamilton, MT 59840, USA. DKocisko@niaid.nih.gov
SP englisch
PO USA