NR AUAQ
AU Head,M.W.; Kouverianou,E.; Taylor,L.; Green,A.; Knight,R.S.G.
TI Evaluation of urinary PrPsc as a diagnostic test for sporadic, variant, and familial CJD
QU Neurology 2005 May 24; 64(10): 1794-6
PT evaluation studies; journal article
AB Previously collected urine specimens from 100 patients referred to the UK National CJD Surveillance Unit as suspected cases of Creutzfeldt-Jakob disease (CJD) were analyzed, testing for abnormal prion protein (PrPsc). In this context, the test had a low sensitivity and was not completely specific for CJD. Additionally, the proteins detected by this assay were not PrPsc but appeared to be immunoglobulins.
MH Antibody Specificity/immunology; Blotting, Western/methods/standards; Creutzfeldt-Jakob Syndrome/*diagnosis/immunology/*urine; Cross Reactions/immunology; Humans; Immunoglobulins/immunology/*urine; PrPsc Proteins/immunology/*urine; Predictive Value of Tests; Reproducibility of Results; Research Support, Non-U.S. Gov't; Urinalysis/methods/standards; Urine/*chemistry
AD National CJD Surveillance Unit, School of Molecular and Clinical Medicine, University of Edinburgh, UK. m.w.head@ed.ac.uk
SP englisch
PO USA