NR ATZH
AU Bürger,K.; Otto,M.; Teipel,S.J.; Zinkowski,R.; Blennow,K.; DeBernardis,J.; Kerkman,D.; Schröder,J.; Schönknecht,P.; Cepek,L.; McCulloch,C.; Möller,H.J.; Wiltfang,J.; Kretzschmar,H.A.; Hampel,H.
TI Dissociation between CSF total tau and tau protein phosphorylated at threonine 231 in Creutzfeldt-Jakob disease
QU Neurobiology of Aging 2006 Jan; 27(1): 10-5
PT controlled clinical trial; journal article
AB To study the potential diagnostic value of abnormally phosphorylated tau protein in Creutzfeldt-Jakob disease (CJD) compared to Alzheimer's disease (AD), we determined levels of tau phosphorylated at threonine 231 (p-tau231) and of total tau (t-tau) in cerebrospinal fluid (CSF) of CJD patients, AD patients, and healthy controls (HC). CJD patients showed excessively high t-tau levels but relatively low p-tau(231) concentrations compared to the AD group. t-tau alone yielded the best diagnostic accuracy to differentiate between CJD and AD patients, when compared to p-tau231 and the p-tau231/t-tau ratio (97, 78, and 95% correctly allocated cases, respectively). Our findings indicate a dissociation in the direction of change in CSF levels of t-tau and p-tau231 in CJD when compared to AD.
MH Age Distribution; Aged; Alzheimer Disease/*cerebrospinal fluid/*diagnosis/epidemiology; Biological Markers/cerebrospinal fluid; Creutzfeldt-Jakob Syndrome/*cerebrospinal fluid/*diagnosis/epidemiology; Diagnosis, Differential; Female; Germany/epidemiology; Humans; Male; Middle Aged; Phosphorylation; Prevalence; Reproducibility of Results; Research Support, Non-U.S. Gov't; Sensitivity and Specificity; Sex Distribution; Statistics; Threonine/*metabolism; tau Proteins/*cerebrospinal fluid
AD Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig-Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany. katharina.buerger@med.uni-muenchen.de
SP englisch
PO USA