NR ATYT
AU Aralasmak,A.; Crain,B.J.; Zou,W.Q.; Yousem,D.M.
TI A prion disease - possible Gerstmann-Sträussler-Scheinker disease: a case report.
QU Journal of Computer Assisted Tomography 2006 Jan-Feb; 30(1): 135-9
PT case reports; journal article
AB A 50-year-old patient with a 6-month history of progressive cognitive and motor disability is presented. There were no myoclonic jerks on examination and no periodic sharp waves by electroencephalography. Imaging showed high signal on T2-weighted scans in the basal ganglia and posterior limbs of the internal capsules, with no restricted diffusion and parenchymal volume loss. A brain biopsy was performed. Western blot analysis revealed a protease-resistant prion protein fragment (PrP7-8), the molecular hallmark of Gerstmann-Sträussler-Scheinker disease.
MH Blotting, Western; Diagnosis, Differential; Electroencephalography; Gerstmann-Sträussler-Scheinker Disease/*diagnosis/surgery; Humans; *Magnetic Resonance Imaging; Male; Middle Aged
AD Ayse Aralasmak (aysearalasmak@hotmail.com), David M. Yousem, Russell H. Morgan Department of Radiology and Radiological Science, Division of Neuroradiology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA; Barbara J. Crain, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Wen-Quan Zou, Institute of Pathology, Neuropathology Division, Case Western Reserve University, Cleveland, OH, USA
SP englisch
PO USA