NR ATYR
AU Angers,R.C.; Browning,S.R.; Seward,T.S.; Sigurdson,C.J.; Miller,M.W.; Hoover,E.A.; Telling,G.C.
TI Prions in skeletal muscles of deer with chronic wasting disease
QU Science 2006 Feb 24; 311(5764): 1117
IA http://www.cwd.cc/Prions%20in%20Skeletal%20Muscles%20of%20Deer%20with%20Chronic%20Wasting%20Disease.pdf
PT journal article
AB The emergence of chronic wasting disease (CWD) in deer and elk in an increasingly wide geographic area, as well as the interspecies transmission of bovine spongiform encephalopathy to humans in the form of variant Creutzfeldt Jakob disease, have raised concerns about the zoonotic potential of CWD. Because meat consumption is the most likely means of exposure, it is important to determine whether skeletal muscle of diseased cervids contains prion infectivity. Here bioassays in transgenic mice expressing cervid prion protein revealed the presence of infectious prions in skeletal muscles of CWD-infected deer, demonstrating that humans consuming or handling meat from CWD-infected deer are at risk to prion exposure.
IN Die Autoren fanden in Skelettmuskeln CWD-infizierter Hirsche per Bioassay Infektiosität.
MH Animals; Brain Chemistry; *Deer; Humans; Mice; Mice, Transgenic; Muscle, Skeletal/*chemistry; PrPsc Proteins/*analysis; Prions/*analysis; Research Support, N.I.H., Extramural; Tissue Extracts/administration & dosage; Wasting Disease, Chronic/*metabolism/*transmission
AD
Shawn R. Browning*, Department of Infectology, Scripps Research Institute, 5353 Parkside Drive, RF-2, Jupiter, FL, 33458, USA;
Rachel C. Angers*, Glenn C. Telling (gtell2@uky.edu), Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky, Lexington, KY 40536, USA; Tanya S. Seward,2 Glenn C. Telling (gtell2@uky.edu), Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40536, USA; Glenn C. Telling (gtell2@uky.edu), Department of Neurology, University of Kentucky, Lexington, KY 40536, USA; Christina J. Sigurdson, Institute of Neuropathology, University of Zürich, Schmelzbergstrasse 12, 8091 Zürich, Switzerland; Edward A. Hoover, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA; Michael W. Miller, Colorado Division of Wildlife, Wildlife Research Center, Fort Collins, CO 80526, USA; *These authors contributed equally to this work
SP englisch
PO USA