NR ATPP
AU Thomzig,A.; Cardone,F.; Krüger,D.; Pocchiari,M.; Brown,P.W.; Beekes,M.
TI Pathological Prion Protein in Muscles of Rodents Infected with BSE or vCJD
QU International Conference - Prion 2005: Between fundamentals and society's needs - 19.10.-21.10.2005, Congress Center Düsseldorf - Poster Session: Pathogenesis PATH-26
PT Konferenz-Poster
AB Recently, pathological prion protein PrPtse was detected in muscles from sheep infected with scrapie, the archetype of transmissible spongiform encephalopathies (TSEs). This finding has highlighted the question of whether mammalian muscle may potentially also provide a reservoir for TSE agents related to Bovine Spongiform Encephalopathy (BSE) and variant Creutzfeldt-Jakob Disease (vCJD). We here report results from studies in hamsters and mice which provide direct experimental evidence, for the first time, of BSE- and vCJD-associated PrPtse deposition in muscles. Our findings emphasize the need for further assessment of possible public health risks from TSE involvement of skeletal muscle.
AD
Achim Thomzig, Dominique Krüger, Michael Beekes, Robert Koch-Institut, P24;
Franco Cardone, Maurizio Pocchiari, Instituto Superiore di Sanità, Department of Cell Biology and Neurosciences, Rome, Italy; Paul Brown, Bethesda, Maryland, USA
SP englisch
PO Deutschland