NR ATMV
AU Clark,S.J.; Hoffmann,R.W.; Baier,M.; Oidtmann,B.
TI Prion Proteins in fish: Expression profiles of duplicated fish prion protein genes in teleost fish
QU International Conference - Prion 2005: Between fundamentals and society's needs - 19.10.-21.10.2005, Congress Center Düsseldorf - Poster Session: Genetics, strains and emerging problems GEN-21
PT Konferenz-Poster
AB
The question of whether fish might be susceptible to developing a Transmissible Spongiform Encephalopathy (TSE) still awaits answering.
We have been able to identify duplicated PrP cDNAs in a suite of fish species and present data on their expression profiles. Expression varies depending on the PrP gene and the fish species investigated.
It still remains unclear how many genes coding for homologues to the mammalian Prion Protein gene exist in fish genomes. Up to eight genes are a reasonable number to be expected.
Our findings illustrate that the situation regarding PrP genes in fish is far more complex than in mammals. More work is required to identify further homologues to mammalian PrP genes in fish. Only with a more comprehensive knowledge on Prion Proteins in fish and further experimental data can we come to a conclusive answer regarding the susceptibiliy of individual fish species to TSEs or the potential of fish to serve as a source of infectious Prions in the absence of clinical disease.
AD S.J.Clark, R.W.Hoffmann, Institute of Zoology, Fish Biology and Fish Diseases, Munich, Germany; M.Baier, Robert-Koch-Institute, Berlin, Germany; S.J.Clark, B.Oidtmann, CEFAS Weymouth Laboratory, Barrack Road, The Nothe, Weymouth, Dorset, DT4 8UB, UK
SP englisch
PO Deutschland