NR ATIZ
AU Dickinson,J.; Leod,A.Mc.; Hall,G.A.; Dennis,M.J.; Murdoch,H.; Walker,J.T.; Sutton,J.M.; Raven,N.D.H.
TI Where do we set the standard for prion decontamination?
QU International Conference - Prion 2005: Between fundamentals and society's needs - 19.10.-21.10.2005, Congress Center Düsseldorf - Poster Session: Decontamination DEC-06
PT Konferenz-Poster
AB
The emergence of variant CJD (vCJD) has raised concerns that there may be significant numbers of people incubating the disease at a pre-clinical or sub-clinical level. Since (v)CJD is transmissible by surgery, transplant and probably by blood transfusion, and the agent(s) responsible largely unaffected by standard sterilisation procedures, there are important implications for public health.
A number of methods for the decontamination of surgical instruments have been described and a range of products are currently seeking regulatory approval. The task of trying to define which of these products provides an adequate safety margin to protect patients and healthcare workers is complicated by the diverse array of experimental animal models, the intrinsic properties of individual TSE strains and the inactivation technologies themselves.
The HPA is currently assessing the ability of thermostable proteases to offer an effective, inexpensive, user and environment friendly alternative to autoclaving or chemical treatment. This technology has demonstrated a > 7-log reduction in the infectivity titre of BSE301V in VM mice and offers the potential to provide an effective process to combat the iatrogenic transmission of vCJD.
These protease decontamination studies have highlighted some of the issues regarding the appropriate standards required to safeguard human health from the continued threat posed by iatrogenic transmission of CJD. These issues will be identified and discussed in the context of public health protection.
IN Durch Baden in einer Enzymlösung konnten die Autoren die Infektiosität TSE-infektiöser Oberflächen um 7 Größenordnungen reduzieren.
AD J.Dickinson, A.Mc.Leod, G.A.Hall, M.J.Dennis, H.Murdoch, J.T.Walker, J.M.Sutton, N.D.H.Raven, Health Protection Agency, UK
SP englisch
PO Deutschland