NR ATED
AU Seeger,H.; Heikenwalder,M.; Zeller,N.; Kranich,J.; Schwarz,P.; Gaspert,A.; Seifert,B.; Miele,G.; Aguzzi,A.
TI Coincident scrapie infection and nephritis lead to urinary prion excretion
QU Science 2005 Oct 14; 310(5746): 324-6
PT journal article
AB Prion infectivity is typically restricted to the central nervous and lymphatic systems of infected hosts, but chronic inflammation can expand the distribution of prions. We tested whether chronic inflammatory kidney disorders would trigger excretion of prion infectivity into urine. Urinary proteins from scrapie-infected mice with lymphocytic nephritis induced scrapie upon inoculation into noninfected indicator mice. Prionuria was found in presymptomatic scrapie-infected and in sick mice, whereas neither prionuria nor urinary PrPsc was detectable in prion-infected wild-type or PrPc-overexpressing mice, or in nephritic mice inoculated with noninfectious brain. Thus, urine may provide a vector for horizontal prion transmission, and inflammation of excretory organs may influence prion spread.
IN Weder bei nichtinfizierten, noch bei PrPc überexprimierenden oder "nur" Scrapie-infizierten Hausmäusen, aber bei Scrapie-infizierten Hausmäusen mit einer lymphozytischen Nierenentzündung fand man PrPsc und Scrapie-Infektiosität im Urin.
MH Animals; Brain/metabolism/pathology; Mice; Mice, Inbred C57BL; Mice, Inbred NZB; Nephritis/complications/*urine; PrPsc Proteins/*urine; Research Support, Non-U.S. Gov't; Scrapie/complications/pathology/transmission/*urine
AD Institute of Neuropathology, University Hospital of Zürich, Schmelzbergstrasse 12, CH-8091 Zürich, Switzerland.
SP englisch
PO USA