NR ASVC
AU Madhavaiah,C.; Verma,S.
TI Copper-metalated peptide palindrome derived from prion octarepeat: synthesis, aggregation, and oxidative transformations.
QU Bioorganic and Medicinal Chemistry 2005 May 2; 13(9): 3241-8
PT journal article
AB We report construction of a bis-pentapeptide conjugate 4 containing truncated pentapeptide sequence from prion octarepeats. Its copper-laden derivative 5 demonstrated a propensity for aggregate formation, which was studied by atomic force microscopy. Oxidative biochemical transformations catalyzed by 5 were evaluated by nucleic acid cleavage and by neurotransmitter oxidation, in the presence of external co-oxidants. Preliminary mechanistic analysis provides a hint for the involvement of reactive oxygen species in such transformations.
MH Amino Acid Motifs/physiology; Catalysis; Copper/*chemistry; Molecular Conformation; Nucleic Acids/chemistry; Oligopeptides/*chemical synthesis/*chemistry; Oxidation-Reduction; Prions/*chemical synthesis/*chemistry; Reactive Oxygen Species/chemistry; Repetitive Sequences, Amino Acid/physiology; Research Support, Non-U.S. Gov't; Spectrometry, Mass, Electrospray Ionization
AD Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur 208016, India.
SP englisch
PO England