NR ASOX
AU Ebringer,A.; Rashid,T.; Wilson,C.; Boden,R.; Thompson,E.
TI A possible link between multiple sclerosis and Creutzfeldt-Jakob disease based on clinical, genetic, pathological and immunological evidence involving Acinetobacter bacteria
QU Medical Hypotheses 2005; 64(3): 487-94
PT journal article
AB Multiple sclerosis (MS) is an immune-mediated demyelinating disease of the nervous system. There is an increasingly likelihood that MS could be triggered/perpetuated by environmental (microbial) agents. Sporadic Creutzfeldt-Jakob disease (sCJD) is a relatively rare but fatal disease, which shows various clinical, genetic, pathological and immunological features through which it resembles a severe form of MS. The disease in some patients with MS may show a rapidly downhill course with death occurring within one to two years and a similar situation occurs in sCJD. The occurrence of these comparative similarities between MS and sCJD could be explained on the basis that both of these conditions might be sharing a common aetiopathogenic factor such as infection by Acinetobacter microbes and this possibility could be investigated further by carrying out immunological studies on a relatively large numbers of patients with MS and CJD.
MH Acinetobacter/*pathogenicity; Acinetobacter Infections/immunology/pathology/physiopathology; Comparative Study; *Creutzfeldt-Jakob Syndrome/genetics/immunology/pathology/physiopathology; Humans; *Multiple Sclerosis/genetics/immunology/pathology/physiopathology; Research Support, Non-U.S. Gov't
AD Infection and Immunity Group, Division of Health and Life Sciences, King's College London, 150 Stamford Street, London SE1 9NN, UK. alan.ebringer@kcl.ac.uk
SP englisch
PO Schottland