NR ARPB
AU Ermolenko,D.N.; Zherdev,A.V.; Dzantiev,B.B.
TI Antibodies as specific chaperones
QU Biochemistry (Moscow) 2004 Nov; 69(11): 1233-8
PT journal article; review; review, tutorial
AB Protein folding is often accompanied by formation of non-native conformations leading to protein aggregation. A number of reports indicate that antibodies can facilitate folding and prevent aggregation of protein antigens. The influence of antibodies on folding is strictly antigen specific. Chaperone-like antibody activity may be due to the stabilization of native antigen conformations or folding transition states, or screening of aggregating hydrophobic surfaces. Taking advantage of chaperone-like activity of antibodies for immunotherapy may prove to be a promising approach to the treatment of Alzheimer's and prion-related diseases. Antibody-assisted folding may enhance renaturation of recombinant proteins from inclusion bodies.
ZR 56
MH Animals; Antibodies/chemistry/immunology/*metabolism; Catalysis; Humans; Molecular Chaperones/chemistry/*metabolism; Muramidase/metabolism; Protein Folding
AD Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, 119071, Russia.
SP englisch
PO USA