NR ARHV
AU Kempster,S.; Collins,M.E.; Edington,N.
TI Time of transforming growth factor beta 1 inoculation alters the incubation of BSE in mice
QU Neuroreport 2004 Oct 5; 15(14): 2233-6
PT journal article
AB Groups of 20 C57BL/6J mice (10 males and 10 females) were given BSE strain 301C i.p. and subsequently given 2 microg recombinant human TGFbeta1 s.c. at single or multiple times. There was a significant positive correlation between the day of TGFbeta1 administration and incubation time; the later TGFbeta1 was administered after BSE inoculation the longer the incubation time became. The administration of TGFbeta1 at any time point did not significantly alter the distribution or severity of pathology. The effects of TGFbeta1 on BSE pathogenesis appears to be dependent upon its time of administration; early administration shortens the incubation time and late administration lengthens the incubation time.
IN Bei intrazerebral mit BSE infizierten Hausmäusen wird die Inkubationszeit verkürzt, wenn kurz nach der BSE-Inokulation TGFß1 subcutan injiziert wird. Wird TGFß1 erst lange nach der BSE-Inokulation injiziert, dann verlängert sich im Gegenteil die Inkubationszeit.
MH Animals; Cattle; Comparative Study; Encephalopathy, Bovine Spongiform/*drug therapy/*pathology; Female; Humans; Male; Mice; Mice, Inbred C57BL; Time Factors; Transforming Growth Factor beta/*administration & dosage
AD Royal Veterinary College, Department of Pathology and Infectious diseases, Royal College Street, London, NW1 0TU, UK. skempster@rvc.ac.uk
SP englisch
PO England