NR ARGA
AU Burwinkel,M.; Riemer,C.; Schwarz,A.; Schultz,J.; Neidhold,S.; Bamme,T.; Baier,M.
TI Role of cytokines and chemokines in prion infections of the central nervous system
QU International Journal of Developmental Neuroscience 2004 Nov; 22(7): 497-505
PT journal article; review; review, tutorial
AB Prion infections of the central nervous system (CNS) are characterised by a reactive gliosis and the subsequent degeneration of neuronal tissue. The activation of glial cells, which precedes neuronal death, is likely to be initially caused by the deposition of misfolded, proteinase K-resistant, isoforms (termed PrPres) of the prion protein (PrP) in the brain. Cytokines and chemokines released by PrPres-activated glia cells may contribute directly or indirectly to the disease development by enhancement and generalisation of the gliosis and via cytotoxicity for neurons. However, the actual role of prion-induced glia activation and subsequent cytokine/chemokine secretion in disease development is still far from clear. In the present work, we review our present knowledge concerning the functional biology of cytokines and chemokines in prion infections of the CNS.
ZR 93
MH Animals; Central Nervous System/*metabolism; Central Nervous System Infections/complications/metabolism/pathology; Chemokines/*metabolism; Cytokines/*metabolism; Humans; Neurodegenerative Diseases/etiology/metabolism/pathology; Neuroglia/*metabolism; Neurons/*metabolism; Prion Diseases/complications/*metabolism/pathology; Prions/*metabolism; Research Support, Non-U.S. Gov't
AD Robert-Koch-Institute, Nordufer 20, 13353 Berlin, Germany.
SP englisch
PO England