NR AREU
AU Klingenstein,R.; Melnyk,P.; Korth,C.
TI Potentiating antiprion effects of quinacrine
QU TSE-Forum, 4. Kongress - Nationale TSE-Forschungsplattform, Düsseldorf 28.10.-29.10.2004, Poster THE-04
PT Konferenz-Poster
AB
Prion diseases are invariable fatal, transmissible neurodegenerative diseases that are characterised by the accumulation of PrPsc, a misfolded isoform of the normal host prion protein (PrPc). They manifest as spontaneous, inherited and infectious diseases with no existing pharmacological treatment.
Previously, acridine derivatives like quinacrine were described to display antiprion effects in a cell model of prion disease (ScN2a cells). We have screened a library of another family of antimalarial substances, quinoline derivatives, for antiprion effects and report about a series of bis- and trisquinolines with strong (>0.1 micM) antiprion activity in ScN2a cells.
Supported by a grant from the BMBF
AD Ralf Klingenstein, Carsten Korth, Institute for Neuropathology, Heinrich Heine University of Duesseldorf; Patricia Melnyk, Universite de Lille
SP englisch
PO Deutschland
OR Tagungsband