NR ARDS
AU Grau,H.; Rosner,C.; Kiesel,P.; Zerr,I.; Gibson,T.; Zischler,H.; Kaup,F.J.; Bodemer,W.
TI Prion diseases and transcription of short interspersed nuclear elements (SINE/Alu)
QU TSE-Forum, 4. Kongress - Nationale TSE-Forschungsplattform, Düsseldorf 28.10.-29.10.2004, Poster GL-01
PT Konferenz-Poster
AB
Short interspersed elements (SINEs) are repetitive elements that make up almost half of the the human and non-human genome. Their function is unknown. Transcripts of the DNA elements have been discussed as mediators of gene expression, especially protein synthesis. According to a hypothesis by T. Gibson, Alu transcripts may be involved in controlling the intracellular prionprotein synthesis. To scrutinise a functional role of these transcripts we have established a study to determine the Alu transcripts in peripheral blood cells of patients and controls. In parallel to the investigation of human blood we have included blood samples from rhesus monkeys inoculated with BSE, vCJD and sCJD.
[project was funded by the DFG, ZI 568/3-1(2)]
AD H. Grau, C. Rosner, P. Kiesel, F.-J. Kaup and W. Bodemer, Dept. of infectious pathology, German Primate Center (DPZ), Kellnerweg 4, 37077 Göttingen, Germany; I. Zerr, Dept. of neurology, University hospital Göttingen, Robert-Koch Str. 40, 37075 Göttingen, Germany; T. Gibson, EMBL Heidelberg, Meyerhofstrasse 1, 69117 Heidelberg, Germany; H. Zischler, Dept. of Anthropology, University Mainz, Saarstr. 21, D 55128 Mainz
SP englisch
PO Deutschland
OR Tagungsband