NR ARAZ
AU Pomfrett,C.J.D.; Glover,D.G.; Bollen,B.G.; Pollard,B.J.
TI Perturbation of heart rate variability in cattle fed BSE-infected material
QU The Veterinary Record 2004 May 29; 154(22): 687-91
PT journal article
AB The brainstem is the region of the brain of cattle with the highest concentration of the abnormal prion protein associated with bovine spongiform encephalopathy (BSE), and specific nuclei in the medulla oblongata of the brainstem, which exhibit changes as a result of the disease, are involved in the modulation of heart rate variability (HRV). The low- and high-frequency components of the HRV of 48 control cattle, 43 cattle fed 1 g of brain homogenate from BSE field cases and 42 cattle fed 100 g of brain homogenate from BSE field cases were analysed repeatedly for a year. There was a significant difference (P<0.001) between the level of high-frequency HRV observed in the control cattle and in both groups of cattle exposed to BSE. There was also a significant difference (P<0.01) between the low-frequency HRV of the cattle given the high dose and the other two groups.
MH Animals; Case-Control Studies; Cattle; Electrocardiography/veterinary; Encephalopathy, Bovine Spongiform/*physiopathology; Food Contamination; *Heart Rate; Medulla Oblongata/physiopathology
AD Anaesthesia Research Group, University of Manchester, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL.
SP englisch
PO England