NR AQTV
AU Tuite,M.F.; Koloteva-Levin,N.
TI Propagating prions in fungi and mammals
QU Molecular Cell 2004 Jun 4; 14(5): 541-52
PT journal article; review; review, tutorial
AB Prions constitute a rare class of protein, which can switch to a robust amyloid form and then propagate that form in the absence of a nucleic acid determinant, thereby creating a unique, protein-only infectious agent. Details of the mechanism that drives conversion to the prion form and then subsequent propagation of that form are beginning to emerge using a range of in vivo and in vitro approaches. Recent studies on both mammalian and fungal prions are providing a greater understanding of the structural features that distinguish prions from non-transmissible amyloids.
ZR 117
MH Amyloid/metabolism; Animals; Cell-Free System; Fungal Proteins/*metabolism; Human; Mammals/*metabolism; Models, Biological; Prion Diseases/*metabolism/transmission; Prions/chemistry/*metabolism; Protein Folding; Protein Structure, Tertiary/physiology; Support, Non-U.S. Gov't
AD Department of Biosciences, University of Kent, Canterbury, Kent CT2 7NJ, United Kingdom.
SP englisch
PO USA