NR AQTU
AU Trzesniewska,K.; Brzyska,M.; Elbaum,D.
TI Neurodegenerative aspects of protein aggregation
QU Acta Neurobiologiae Experimentalis 2004; 64(1): 41-52
PT journal article; review; review literature
AB Protein aggregation and amyloid fibril deposits are characteristic features of more than twenty pathologic conditions characterized by plaque deposition in the central nervous system. Recent studies point out relationships between protein misfolding and numerous serious diseases. Despite different origins (sporadic, familial or transmissible), they are sometimes called conformational diseases to emphasize aberrant conformations as the putative cause of deposits that precede or accompany the clinical manifestation of the disease. Neurological disorders such as Alzheimer's disease (AD), Prion disorders (PrD), Parkinson's disease (PD), and Huntington's disease (HD) are the most typical examples of protein-based dementias, characterized by protein conformational transitions (alpha-helix/random coil to beta-sheet) that cause aggregation followed by fibrillization. Although it is very tempting to postulate a common mechanism of toxicity based on conformational and structural analogies, it should be noted that the factors responsible for conformational transition, oligomerization, aggregation, and plaque formation, are still subject of speculation and additional data is required to test the amyloid fibril hypothesis.
ZR 138
MH Alzheimer Disease/*metabolism/*pathology; Amyloid beta-Protein/*metabolism; Human; Huntington Disease/metabolism/pathology; Nerve Degeneration/*metabolism/*pathology; Prions/metabolism; Support, Non-U.S. Gov't
AD Katarzyna Trzeoeniewska (kpergol@nencki.gov.pl), Maria Brzyska and Danek Elbaum, Laboratory of Bio-Physical Methods, Nencki Institute of Experimental Biology, 3 Pasteura St., 02-093 Warsaw, Poland
SP englisch
PO Polen