NR AQOG
AU Ryder,S.J.; Dexter,G.; Bellworthy,S.J.; Tongue,S.
TI Demonstration of lateral transmission of scrapie between sheep kept under natural conditions using lymphoid tissue biopsy
QU Research in Veterinary Science 2004 Jun; 76(3): 211-7
PT journal article
AB Scrapie free adult sheep were introduced to a sheep flock specifically maintained to maximise scrapie infection. Native born sheep of the highly susceptible VRQ/VRQ genotype in this flock show highly efficient transmission, evidenced by 100% infection, with an age at death of less than 2 years. Infection in introduced sheep was identified by biopsy of tonsilar and nictitating membrane lymphoid tissue. Progeny of these sheep were monitored and clinical disease confirmed by examination of the brain using routine diagnostic methods. Naive sheep of New Zealand origin introduced to the flock in adulthood became infected, demonstrating that lateral transmission had occurred. Lambs born to introduced ewes became infected and died at the same age as lambs born to native ewes, consistent with lateral transmission of scrapie to lambs. Although maternal transmission cannot be totally excluded for the lambs in this study, the data are consistent with lateral transmission being the most important means of spread leading to the high incidence of scrapie observed in this flock.
IN Die Autoren brachten Scrapie-freie Schafe aus Neuseeland mit dem hochempfänglichen Genotyp VRQ/VRQ in eine stark von Scrapie betroffene britische Schafherde. Alle diese Schafe wurden allein durch die gemeinsame Haltung mit Scrapie-Schafen oder durch das Weiden auf einer kontaminierten Weide infiziert und erkrankten im Alter von weniger als 2 Jahren. Auch die Nachkommen dieser Schafe erkrankten an Scrapie, aber sie erkrankten nicht früher als der Nachwuchs nicht infizierter Mütter. Dies schließt eine maternale Übertragung zwar nicht völlig aus, aber horizontale Übertragung scheint bei Scrapie eine erheblich bedeutendere Rolle zu spielen, falls es eine maternale Übertraung überhaupt gibt.
MH Alleles; Animals; Biopsy/veterinary; Cohort Studies; Disease Transmission, Horizontal/*veterinary; Female; Genetic Predisposition to Disease; Male; Nictitating Membrane/pathology; Pregnancy; Scrapie/genetics/*transmission; Sheep; Support, Non-U.S. Gov't; Tonsil/pathology
AD Department of Pathology, Veterinary Laboratories Agency, Woodham Lane, New Haw, Addlestone, Surrey KT15 3NB, UK. s.ryder@vla.defra.gsi.gov.uk
SP englisch
PO England
ZF Zusammenfassung des Abstracts von Roland Heynkes