NR AQDE
AU Kamae,I.; Nakajo,K.; Aino,H.; Yanagisawa,S.
TI [The analysis of the sensitivity and the specificity of the mass screening system of BSE]
QU Rinsho Byori. Japanese Journal of Clinical Pathology 2003 Dec; 51(12): 1184-7
PT journal article
AB Since the first infected case of BSE(Bovine Spongiform Encephalopathy) was identified in September, 2001 in Japan, Japanese people have been deeply concerned about safety of meat despite a mass screening system established by Japanese government. In the system all the cows for food must be examined with ELISA as screening and additionally with more accurate tests such as western blot etc. if the screened result is positive. To investigate the accuracy of the system, we calculated the number of false negatives and positives using computer simulation. Consequently, the sensitivity analysis towards ELISA showed that even if Japanese cattle were in a low risk group, a few of them are likely to be misdiagnosed as "negative" in spite of true BSE under the current screening system. Also we indicated how to improve the current system to get less false negatives. We believe the analysis of this study can contribute to risk communication with people to minimize the fear or irrationality caused by BSE epidemic.
IN Der erste japanische BSE-Fall wurde im September 2001 entdeckt. Daraufhin wurde entschieden, alle japanischen Rinder nach ihrem Tod per ELISA einem BSE-Schnelltest zu unterziehen. So gewonnene Verdachtsfälle werden vermeintlich akurateren Tests wie einem Western blot unterzogen. Dem Abstract dieses ansonsten leider japanischen Artikel ist nicht zu entnehmen, was dann geschieht und wie es möglich war, die Zahlen der falsch negativ und falsch positiven Testergebnisse in Japan durch Computersimulationen zu ermitteln. Irgendetwas scheinen die Autoren dabei aber falsch gemacht zu haben, die sie kommen nur auf wenige falsch-negative.
MH Animals; Cattle; Encephalopathy, Bovine Spongiform/*diagnosis; English Abstract; Mass Screening/standards/*veterinary; Sensitivity and Specificity
AD Division of Health Informatics and Sciences, Graduate School of Medicine, Kobe University, Kobe 650-0017.
SP japanisch
PO Japan