NR APYK
AU Tabaton,M.; Monaco,S.; Cordone,M.P.; Colucci,M.; Giaccone,G.; Tagliavini,F.; Zanusso,G.
TI Prion deposition in olfactory biopsy of sporadic Creutzfeldt-Jakob disease
QU Annals of Neurology 2004 Feb; 55(2): 294-6
PT case reports; journal article
AB Currently, definite peripheral markers for the in vivo diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) are not available. Here, we report the presence of pathological prion protein in the olfactory mucosa of a case with sporadic Creutzfeldt-Jakob disease. Prion protein immunoreactivity was detected in an olfactory biopsy performed 45 days after the disease onset, suggesting that the involvement of olfactory epithelium is an early event in sporadic Creutzfeldt-Jakob disease.
MH Biopsy; Brain Chemistry; Creutzfeldt-Jakob Syndrome/*pathology/physiopathology; Female; Human; Immunohistochemistry; Middle Aged; Olfactory Mucosa/*metabolism/pathology; PrPsc Proteins/*metabolism; Support, Non-U.S. Gov't
AD Department of Neurosciences, University of Genoa, Genoa, Italy. mtabaton@neurologia.unige.it
SP englisch
PO USA