NR APXY
AU Kulczycki,J.; Lojkowska,W.
TI [The clinical and laboratory diagnosis of sCJD and vCJD]
OT Diagnostyka kliniczna i laboratoryjna choroby Creutzfeldta-Jakoba (sCJD i vCJD)
QU Neurologia i Neurochirurgia Polska 2003; 37 Suppl 2: 7-14
PT journal article
AB Clinical diagnosis of sporadic CJD is usually confirmed by a typical EEG pattern and an increased level of protein 14-3-3 in the CSF, with specificity of 74% and 84%, respectively. However, both these tests are often negative in vCJD patients. Recently MR imaging has substantially improved the diagnosis of sCJD and vCJD. In sCJD patients hyperintense signal in T2-weighted sequences was found to be present in the neostriatum (the caudate nucleus and putamen) with specificity of 93%, while in vCJD cases signal hyperintensity was found in pulvinar thalami. The "pulvinar sign" was evidenced to be highly sensitive (79%) and specific (100%) for the diagnosis of the latter form of CJD.
MH Brain/pathology/physiopathology; Creutzfeldt-Jakob Syndrome/cerebrospinal fluid/*diagnosis; Electroencephalography; English Abstract; Human; Magnetic Resonance Imaging; Sensitivity and Specificity; Tyrosine 3-Monooxygenase/cerebrospinal fluid
AD I Kliniki Neurologicznej Instytutu Psychiatrii i Neurologii w Warszawie.
SP polnisch
PO Polen