NR APTZ
AU Bergmann,J.; Bergmann,R.; Janetzky,B.; Singh,S.; Preddie,E.
TI PrPsc-like prion protein conformer in sudden infant death syndrome brain
QU Acta Neuropathologica 2004 Jan; 107(1): 66-8
PT journal article
AB Nothing is known about the pathophysiology of sudden infant death syndrome (SIDS). Here we show the presence of misfolded prion protein (PrPsc-like) in extracts of various sections of the brains of two SIDS victims. DNA sequence information for one of these (death at 12 days) revealed two nucleotide variants in the protein coding region of the PrP gene. This may be a key finding in the understanding of SIDS pathology, and may suggest ways for identifying risk factors for SIDS in newborn infants.
MH Adult; Blotting, Western; Brain/*metabolism; Case-Control Studies; Human; Infant; Infant, Newborn; Mutation; PrPsc Proteins/*genetics/metabolism; Protein Folding; Sudden Infant Death/*genetics
AD Altegen Inc., Wilmington, Delaware, USA. altegen@aol.com
SP englisch
PO Deutschland