NR APTN
AU Dranovsky,A.; Goldfarb,L.; Gajdusek,D.C.; Goldgaber,D.
TI Apolipoprotein-e epsilon-4 allele does not correlate with amyloid plaques in transmissible spongiform encephalopathies
QU Amyloid - International Journal of Experimental and Clinical Investigation 1995 Mar; 2(1): 36-8
PT Tech. Note
AB Apolipoprotein E epsilon 4 allele has been repeatedly correlated with late-onset familial and sporadic Alzheimer's disease. Apolipoprotein E has been localized to amyloid plaques of Alzheimer's disease and of transmissible spongiform encephalopathies. In this study, apoE epsilon 4 frequencies were examined in two distinct populations affected by kuru and Creutzfeldt-Jakob disease (two transmissible spongiform encephalopathies with varying amounts of amyloid plaques). We then correlated apolipoprotein E genotypes to neuropathological findings of plaques in the same patients. The results demonstrate both amyloid plaque deposition in the absence of the apolipoprotein E epsilon 4 allele in kuru and lack of amyloid plaque deposition in the presence of the apolipoprotein E epsilon 4 allele in Creutzfeldt-Jakob disease. We conclude that in transmissible spongiform encephalopathies, apolipoprotein E4 does not seem to contribute to the formation of amyloid plaques.
IN Bei Kuru- und Creutzfeldt-Jakob-Patienten wurden amyloide Plaques in Abwesenheit von Apolipoprotein E epsilon 4 Allelen und das Fehlen dieser Plaques in Anwesenheit von Apolipoprotein E epsilon 4 Allelen festgestellt. Aus diesem nicht gerade umwerfend neuartigen Befund schließen die Autoren naiv, die Anwesenheit von Apolipoprotein E epsilon 4 Allelen korreliere nicht mit der Plaque-Bildung.
ZR 12
SP englisch
AD D. Goldgaber, SUNY Stony Brook, Sch Med, Dept Psychiat & Behav Sci, Hsc T10, Stony Brook, NY 11794 USA