NR APSR
AU Dormont,D.; Deslys,J.P.
TI Transmissible spongiform encephalopathies induced by unconventional agents (prions)
QU Medecine et Maladies Infectieuses 1995; 25(NSI): 684-7
PT Article
AB Transmissible spongiform encephalopathies (TSE) are rare lethal diseases characterised by a long asymptomatic period, which might be as long as 35 years in humans, and neuropathological pattern associating neuronal vacuolisation, spongiosis, neuronal death and hypoerastrocytosis. These diseases are induced in humans and animals by unconventional agents (TSA) named also prions or virinos. TSA/prions have unconventional properties; for example, they resist to almost all the chemical and physical processes which inactivate conventional viruses. Iatrogenic TSE [mainly Creutzfeldt-Jakob disease (CJD)] cases have been reported after neurosurgery, treatment with pituitary derived hormones, and cornea and dura mater grafting. In an infected individual TSA associated infectivity depends on the organ : central nervous system has the highest infectivity, spleen and lymph nodes a medium infectivity, and organs like bone or skin do not harbor any detectable infectivity. Therefore, donors with neurologic history and/or treatment with pituitary derived hormones should be considered as potentially infected with TSA, and excluded from blood and tissue donation.
ZR 0
SP französisch