NR APNM
AU Lolli,F.; Mazzanti,B.; Rovero,P.; Papini,A.M.
TI Synthetic peptides in the diagnosis of neurological diseases
QU Current Protein & Peptide Science 2003 Aug; 4(4): 277-84
PT journal article; review; review, tutorial
AB For several years peptides have been used to investigate many aspects of the molecular mechanisms supporting the etiopathogenesis of neurological diseases. Even if well-established and commercially-available assays for the diagnosis of neurological diseases, based on peptides, are presently not available, much research has been focused to the comprehension of the pathogenetic mechanisms of relevant neurological diseases, such as Multiple Sclerosis, Alzheimer's disease and prion diseases. Several peptides, which strongly contributed to increase in the progress, and in the understanding of the molecular mechanisms of these important diseases, have been selected as antigens to be proposed in possible alternative diagnostic methodologies. The authors focused their attention on the possible peptides to be used as diagnostics for these three characteristic neurological diseases. In fact, Multiple Sclerosis is an autoimmune disease in which peptides have been used for the characterization of both B and T immune response, while Alzheimer's disease and prion diseases can be cumulative regarded as "protein folding disorders" in which peptides can be used to identify the misfolded protein.
ZR 121
MH Alzheimer Disease/diagnosis; Amyloid beta-Protein/blood/cerebrospinal fluid/diagnostic use; Animals; Autoantibodies/cerebrospinal fluid; CD4-Positive T-Lymphocytes/immunology; Computer Simulation; Human; Models, Biological; Multiple Sclerosis/diagnosis; Myelin Sheath/immunology; Nervous System Diseases/*diagnosis; Peptide Fragments/blood/cerebrospinal fluid/diagnostic use; Peptides/chemical synthesis/chemistry/*diagnostic use; Prion Diseases/diagnosis; Protein Conformation
AD Azienda Ospedaliera Careggi and Dipartimento di Scienze Neurologiche e Psichiatriche, Universita di Firenze, I-50134 Firenze, Italy.
SP englisch
PO Niederlande