NR APCZ
AU Belay,E.D.; Dobbins,J.G.; Malecki,J.; Buck,B.E.; Bell,M.; Cobb,J.; Schonberger,L.B.
TI Creutzfeldt-Jakob Disease (CJD) in a Recipient of a U.S.-Processed Dura Mater Graft: Cause or Coincidence?
QU Workshop on TSE Risks in Relation to Source Material, Processing, and End-Product Use. June 8-9, 1998, College Park, MD
IA http://www.life.umd.edu/jifsan/tse/belay.htm
PT Workshop
VT
In 1997, CDC was notified about a 72-year-old man who developed CJD 54 months after he received a dura mater graft during removal of a meningioma. CDC confirmed that CJD diagnosis was based on standard clinical criteria, including typical electroencephalographic changes. Investigation of patients who underwent craniotomy within 4 months before or after the case-patient's surgery revealed no evidence for nosocomial transmission of CJD. The dura donor was a previously healthy 34-year-old man with no known risk factors fore CJD who had died in a motor vehicle collision. The dura was processed in the United States with no direct contact with other dura. However, possible indirect contact through water used to rinse dural grafts from about 25 other donors simultaneously could not be ruled out; tracing of recipients of these grafts is in progress. If this case-patient remains the only recipient of a U.S.-processed dural graft with CJD, then this graft-CJD association is more likely to be coincidental than causal. This report underscores the potential importance of recent recommendations to minimize the risk of CJD transmission by such grafts, including neuropathologic screening of all donors and removal of opportunities for cross-contamination among grafts.
Last modified Monday, February 22, 1999 04:33:32
IN 1997 wurde den US-amerikanischen Centers for Disease Control and Prevention (CDC) gemeldet, dass ein 72 Jahre alter Mann 54 Monate nach der Implantation einer dura mater an der Creutzfeldt-Jakob-Krankheit erkrankte. Die Diagnose erfolgte aufgrund klinischer Symptome einschließlich typischer EEG-Veränderungen. Der Spender der dura mater war ein Verkehrsunfallopfer ohne erkennbares CJD-Risiko. Die dura mater wurde in den USA aufbereitet. Dabei vermied man zwar den direkten Kontakt zu anderen duras, benutzte aber das selbe Wasser zum Waschen von 25 Dura mater - Präparationen.
ZR 0
AD Belay,E.D.1; Dobbins,J.G.1; Malecki,J.2; Buck,B.E.3; Bell,M.1; Cobb,J.2; Schonberger,L.B.1; 1 Centers for Disease Control and Prevention (CDC), Atlanta, GA; 2 Palm Beach County Health Department, West Palm Beach, FL; 3 Department of Orthopedics and Rehabilitation, University of Miami School of Medicine, Miami, FL.
SP englisch